Full Metal Alchemist and DBZ are great but I wouldn't say "to get into" FMA is like 4 seasons... and DBZ is.. forever.
 
Watching the current mainstreams that are still going on are better. They relate more to things now adays. I used to watch one piece. It had 500 episodes now. Its unnecessarily long.
the current mainstream is mostly filled with partial nudity and something else i'm not aware of
but One Piece is one out of many good anime shows and even if it's long it is enjoyable and a perfect choice to find out if you like anime or not, also things now a days is not really that good and by that i'm mostly referring to dubstep,hipsters,lame songs that make no sense and that autotune shit.
really even though new can be good not all new is good, and sometimes the old is better
 
Someone already said it, but Death Note is a really good anime to start with (I think that is where I started in fact).
Only 37 episodes, so pretty short compared to a lot of what has been said already.
Here's a clip that gets the gist of what much of the series is about:
 
the current mainstream is mostly filled with partial nudity and something else i'm not aware of
but One Piece is one out of many good anime shows and even if it's long it is enjoyable and a perfect choice to find out if you like anime or not, also things now a days is not really that good and by that i'm mostly referring to dubstep,hipsters,lame songs that make no sense and that autotune shit.
really even though new can be good not all new is good, and sometimes the old is better
all anime have fan service. But there are ones with less.
 
Hmm, trying to cover the bases here.

Fist of the North Star. Classic post-apocalyptic anime, staple of manliness, and a fairly old shonen. Even some of my casual friends like it which is saying a lot seeing as some don't even touch other anime.

Also, Planetes. It's fairly realistic sci-fi drama in terms of tech, though nothing much happens at first since it's about space garbage collectors; I was more of a fan of the manga but the anime's good too. It's also directed by the guy who would go on to direct Code Geass, if that means anything to you.

FLCL. Weird as hell. It's short but it's a good exercise in symbolism if you want to feel smart. If you don't, there's still the top-notch animation in every scene, action or comedic.

Dead Leaves. Basically a prison escape from a moon colony. It's pure, mindless action; don't even think about the plot, it makes less sense that way. Directed by one of the guys who made FLCL so this whole thing comes together as an acid trip with gunshots. A guy has a fucking drill for a penis, tell me that's not the pinnacle of animation.

Neon Genesis Evangelion. Infamous mecha anime and, really, you'll either love this and it's the holy fucking grail or hate it with all your being, both for its characters and the ending. Practically required watching in some circles of anime fandoms. Honestly, it's less confusing than people make it out to be but it can still be a lot to take on in one sitting. Also, to properly finish watching you need to watch End of Evangelion.

Lupin III. Very old, very long since it ran from the early the seventies to the eighties with some OVAs and movies in between, so you can pick and choose to some extent. Hijinks, thefts, chases, perversion eveyr now and then. There's a new series The Woman Called Fujiko Mine, if you want something shorter and more modern; plus, holy shit that delicious art style.

Revolutionary Girl Utena. It's considered the shoujo counterpart to Evangelion, sometimes called Eva with magical girls, roses, and lesbians, but it doesn't cause as many shitstorms. Symbolism abounds here, bro.

Cromartie High School. Freddie motherfucking Mercury's a character in this. That's all you need to know

Azumanga Daioh. Basically the daily life of schoolgirls, only it's a comedy and there's not much fanservice. I laughed, I cried, I hnnnng'd. Along the same line, you might want to try Lucky Star, or Nichijou, the latter specially for some surreal shit.

In general, most of Studio Ghibli's stuff is well known among casuals, so stuff like Spirited Away or Howl's Moving Castle falls under this banner. There's also Grave of the Fireflies if you ever feel like you could afford to be depressed for a couple days.

Boku no Pico. Rite of passage. Do it.
 
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Hmm, trying to cover the bases here.

Fist of the North Star. Classic post-apocalyptic anime, staple of manliness, and a fairly old shonen. Even some of my casual friends like it which is saying a lot seeing as some don't even touch other anime.

Also, Planetes. It's fairly realistic sci-fi drama in terms of tech, though nothing much happens at first since it's about space garbage collectors; I was more of a fan of the manga but the anime's good too. It's also directed by the guy who would go on to direct Code Geass, if that means anything to you.

FLCL. Weird as hell. It's short but it's a good exercise in symbolism if you want to feel smart. If you don't, there's still the top-notch animation in every scene, action or comedic.

Dead Leaves. Basically a prison escape from a moon colony. It's pure, mindless action; don't even think about the plot, it makes less sense that way. Directed by one of the guys who made FLCL so this whole thing comes together as an acid trip with gunshots. A guy has a fucking drill for a penis, tell me that's not the pinnacle of animation.

Neon Genesis Evangelion. Infamous mecha anime and, really, you'll either love this and it's the holy fucking grail or hate it with all your being, both for its characters and the ending. Practically required watching in some circles of anime fandoms. Honestly, it's less confusing than people make it out to be but it can still be a lot to take on in one sitting. Also, to properly finish watching you need to watch End of Evangelion.

Lupin III. Very old, very long since it ran from the early the seventies to the eighties with some OVAs and movies in between, so you can pick and choose to some extent. Hijinks, thefts, chases, perversion eveyr now and then. There's a new series The Woman Called Fujiko Mine, if you want something shorter and more modern; plus, holy shit that delicious art style.

Revolutionary Girl Utena. It's considered the shoujo counterpart to Evangelion, sometimes called Eva with magical girls, roses, and lesbians, but it doesn't cause as many shitstorms. Symbolism abounds here, bro.

Cromartie High School. Freddie motherfucking Mercury's a character in this. That's all you need to know

Azumanga Daioh. Basically the daily life of schoolgirls, only it's a comedy and there's not much fanservice. I laughed, I cried, I hnnnng'd. Along the same line, you might want to try Lucky Star, or Nichijou, the latter specially for some surreal shit.

In general, most of Studio Ghibli's stuff is well known among casuals, so stuff like Spirited Away or Howl's Moving Castle falls under this banner. There's also Grave of the Fireflies if you ever feel like you could afford to be depressed for a couple days.

Boku no Pico. Rite of passage. Do it.
High School of the dead is also a really good anime. It's based on a zombie apocalypse. Also dead man wonderland is good. A kid gets framed for mass murder.
 
Also, fuck, I forgot this.

Jojo's Bizarre Adventure. Holy motherfucking shit on a stick. Seriously long manga, seriously fabulous/manly as hell. Right now there's a series airing that covering the first few chapters. An immortal vampire versus a family of badasses.

Obligatory: most of these are better watched subbed if a dub option is available. The only exceptions are Cromartie High School, Dead Leaves, and FLCL since their dubs are pretty well done; some would argue they're better than the originals..

High School of the dead is also a really good anime. It's based on a zombie apocalypse. Also dead man wonderland is good. A kid gets framed for mass murder.
Eh, manga was better for both. HotD really doesn't do anything new with zombies besides adding even more GIANT ANIMU BREASTS but I like some of the characters and the gun porn. DW, can't say I can judge it. Never got into it for some reason, not to mention it looks like it was toned down from the manga.
 
oh god if you're like into gore and sad tragic stuff, elfen lied is my favorite

otherwise i'd agree with a lot of what people are saying, FMA is wonderful, i love Inuyasha, and if you're into girly stuff I bet you'll love Chobits and Rozen maiden amg yes
 
Sgt Giraffe, please don't rate every post as dumb, that counts as rating spam, and it's against the rules.

Wisdom, there are a shitton of animes out there, they all vary by taste. Personally, I've liked Naruto since it came out, hell I even used to cosplay. I still keep up with the manga, even though people hate it because they only heard of it when it became popular and was ruined by U.S kids.
If you tell us what kind of anime you're looking for, I'm sure a lot of people will be able to help you by giving you a list. Personally, I've gone through Naruto, One Piece, tried getting into Bleach but couldn't, loved Death Note, and a few lesser known animes.